Study of Fenugreek Seed Extract Effect (Trigonella Foenum-Graecum L) on Histomorphic Structure of Cervical Enlargement of the Spinal Cord Development During Gestational Age of 20 Day Offspring of Diabetic Rats
Ebrahim Tavakol Koukhdan* and Zabihollah KhaksarDepartment of Anatomical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz Iran.
Abstract: This study was conducted to evaluate the effects of Fenugreek seed extract (trigonellafoenum-graecum) on development of diabetic rats offspring spinal cord structure, especially in the cervical enlargement. Sixteen healthy female rats were divided into four groups (normal control, diabetic control, control Fenugreek seed and Fenugreek seed treatment). Diabetes was induced in four groups by Streptozotcin(50mg/kg/IP) and mating by male rat and vaginal plaque mentioned as a positive sign of pregnancy. Two groups received extract and the two others were given distilled water. After 20 days rats were scarified and their offspring were removed. Spinal cords were collected, processed and embedded in paraffin and various histological parameters were determined. Results showed that mean body weight of the diabetic control group was significantly higher (P≤ 0/05). Reduction in the vertical and transverse diameters and number of neurons in the diabetic group was significant (P≤ 0/05). Also, mean blood sugar was decreased significantly (p<0.05). Based on the results, it can be concluded that Fenugreek seed extract reduced the blood sugar and diabetes effects in the spinal cord.
Keywords: Fenugreek seed extract -Streptozotocin- Diabetes - Rat - Spinal cord Back to TOC