Periodontal Vaccines: A Sophisticated Treatment Design in the Future?
T. Parthasaradhi1, Preethe Paddmanabhan2 and V. Ramya21Dept. Of Periodontics. Tagore Dental college and Hospital, Chennai. 2Department of Periodontics, Sree Balaji Dental College and Hospital, Bharath University, Pallikaranai, Chennai-600100
Abstract: Periodontal vaccine is a boon in periodontics. The demanding primary role of any periodontal vaccine would be to eradicate the global periodontal disease burden with the ultimate purpose of lowering periodontal disease associated morbidity in humans. In late eighteenth century, Edward Jenner developed and established the principle of vaccination using the cross protection conferred by cowpox virus, which is non pathogenic in humans. Vaccination accomplished can be active immunization, passive immunization or DNA vaccination, made from the antigenic epitopes in periodontopathic bacteria. The objective of periodontal vaccine is to identify the antigens involved in the destructive process of periodontitis against which antibodies would be evoked to exert protection. It also aims to induce mucosal antibody response with little or moderate doses of vaccine. Ongoing research & collaborative efforts can result in development of functional periodontal vaccine for human use in future.
Keywords: Vaccines; Active immunization; Passive immunization; DNA vaccination; Epitope Back to TOC