Synthesis and Antimicrobial Activity of some Pyridazinone Derivatives

S. K. Verma¹, R. Irrchhaiya² , K. P. Namdeo², V. K. Singh², A. Singh² and  S. Khurana³

¹Institute of Pharmacy, Bundelkhand University, Jhansi.

²S.L.T Institute of Pharmaceutical Sciences G.G.U., Bilaspur.

³I.T.S. Paramedical college, Ghaziabad.

Abstract: Some new 6-phenyl–Pyridazine-3-One were synthesized by hydrazinolysis of appropriate b-(substituted aryl) propionic acid, there were converted into corresponding Bis-pyridazinone (IIIa toIIId). All these synthesized compounds were characterized on the bases of spectral data and evaluated for their antimicrobial activity.

Keywords: Pyridazine-3-One; Antibacterial activity; Antifungal activity

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