The Effect of Cinnamon Extract on Gonadotrop in Changes (FSH& LH) in Rats Treated with Gelophen
Pourahmadi Mohammad1, Beheshtimoghadam Zienab2 and Kargar Jahromi Hossein31Department of Anatomy, Jahrom University of Medical Science, Jahrom, Iran
2Department of General of Fars Province Education , Jahrom ,fars , Iran.
3Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Abstract: Gelofen is an Anti-inflammatory drug which by Inhibition of Prostaglandin and cyclooxygenase prevents the conversion ofArachidonicacidto intermediate Endo-peroxides and has numerous effectsonvarious tissuesof thebody. Cinnamonbarkhas many therapeuticproperties;its usestrengthens theheart, stomachandintestines,improvingKidneyactivity. Considering the possible side effects of Gelofen and cinnamon’sbeneficialeffectson the body, the most important objective of the present study is to investigate the effect of Cinnamon on possible side effects of Gelophen in secretion of Estrogenand Progesterone hormones. 42 female Wistarrats were randomly dividedinto 7groups. The first group (the control group ) was not treated with any drugs. The experimental group 1 and 2 only received 50, 200 mg/kg dosage of cinnamon respectively, the experimental group 3 received only Gelofen with 400 mg/kg dosage andthe experimental group 4 and 5 received Gelofen and cinnamon extract with 50 and 200 mg/kg dosages intraperitoneally. At the end of the day 21th, the blood sample was taken from the rats and serum concentrations ofestrogenand progesteronewere measured. Then statistical data were processed with SPSS version 18 using ANOVA test (One- way analysis of variance), they were determined as significant (P< 0.05). The concentration ofEstrogen inthe experimental group 1increasedsignificantlycompared to control group. Progesteroneconcentrationswere significantlydecreasedin the experimental group3 compared to the control group and the experimental group 1 and 2 (P<0.05). Accordingto the aboveit can bestatedthat Gelofen causes a relative decreases in the secretion of estrogenand progesteronehormones by production ofhydroxylradicals and damaging the ovarian tissues, but Cinnamonextractreduces the side effects with its antioxidant properties and effective substances.
Keywords: Cinanamon; Gelofen; Estrogen; Progesterone; Rat Back to TOC