Pathological Changes of Gentamicin in Liver Tissue and Antioxidant Property of Cinnamon Extract on Wistar Rats
Najafian Mahmood1, Mokaber Haleh2, Pourahmadi Mohammad3, Farzam Mohsen4 and Kargar Jahromi Hossein31Department of Biology, Jahrom Branch, Islamic Azad University, Jahrom, Iran.
2Department of Developmental Biology, Science and Research Branch, Islamic Azad University, Fars, Iran.
3Department of Anatomy, Jahrom University of Medical Science, Jahrom, Iran.
4Department of Veterinry, Kazeroon Branch, Islamic Azad University, Kazeroon, Iran.
Abstract: The most vulnerable tissue against damages and side effects of medications is the liver tissue. Among the medications, most frequently used ones are antibiotics with among which toxicity with aminoglycosides, especially gentamicin has special importance. Studies have shown that gentamicin exerts its hepatotexicity poperty through creating free radicals. Cinnamon has antioxidant properties. In This research the antioxidant properties of cinnamon in reducing hepatotexicity poperty caused by gentamicin is studied. In this study, effect of gentamicin as 100mg/kg-BW (G100), cinnamon extract as 200mg/kg-BW (C200) and gentamicin with the dosages of 50, 100 and 200mg/kg-BW of cinnamon extract (GC50, GC100 and GC200) on rats was studied. The results of research show severe destroy of tissue in the liver in group G100. Activity of the pyruvate transaminase enzyme, exhalostat transaminase, and fosfatase alcaline in group G were significantly increased (P <0.05) compared to control group. In group GC50, GC100 and GC200, roughly proportional to the dose of cinnamon extract, enzyme activity reduced compared to group G (P <0.05). The tissue results also indicate tissue damage caused by gentamicin and healing by antioxidant properties of Cinnamon in group GC200. It may be concluded that cinnamon extract with its antioxidantproperties reduces liver damage caused by gentamicin.
Keywords: Hepatoxicity; Gentamicin; Cinnamon; Rats Back to TOC