Synthesis and Antibacterial Activity of some Pyrazolines using more Technique
Ravindra Kumar, Birbal Bajia and Y. K. Srivastava*P. G. Department of Chemistry, M.P. Government College Chittorgarh.
Abstract: Pyrazoline derivatives have their importance due to a variety of industrial applications and wide range of biological activities change in substitution pattern at 1-N position of pyrazoline ring may alter the biological activities of pyrazolines. Therefore some new 1-N substituted pyrazoline derivatives were synthesized using microwave assisted method. The condensation of chalcone with hydrazine gave 3, 5-diaryl-2 pyrazolines which were treated with chloro acetyl chloride followed by reaction with diethyl amine to afford corresponding 1-N substituted 3, 5-diaryl pyrazolines in 80-85% yield. The synthesized compounds were screened for their anti bacterial activities against gram negative and gram positive bacteria.
Keywords: Pyrazoline; microwave assisted; anti bacterial activity Back to TOC