Synovial Fluid Density Measurement for Diagnosis of Arthritis
G. Hari Krishnan1, Anima Nanda1 and Ananda Natarajan R21Department of Biomedical Engineering, Sathyabama University, Chennai, India.
2Department of Electronic and Instrumentation, Pondicherry Engineering College, Pondicherry, India.
Abstract: Synovial fluid generally present in the joint region for the purpose of lubricant as a major task. During arthritis disease affected condition the density of synovial fluid varies as a function of time in case of osteoarthritis and as a function of disease condition in case of rheumatoid arthritis. By measuring the variation in density of synovial fluid arthritis diseases can be diagnosed. In this paper an non invasive method has been adopted for measurement of synovial fluid density change using electrical bio-impedance concept. Electrical Bio-Impedance is the measure of opposition given by the tissue for applied electrical signal. The Bio-impedance values are measured in terms of voltage drop across the joint tissue region as tissue can be represented as resistance and capacitive reactance. These resistance and reactance varies from normal person to Arthritis patient for a fixed frequency and voltage. Hardware section made using signal generator circuit with variable frequency and variable voltage provision. To measure the voltage drop using non invasive method four electrodes has been utilized for given electrical signal and acquiring the response.
Keywords: Synovial fluid density; Arthritis; Electrical bio-impedance; Non invasive diagnosis; Electrodes Back to TOC