Beneficial Effects of Vegetable Oils (Rice Bran and Mustard Oils) on Anti-inflammatory and Gastro Intestinal Profiles of Indomethacin in Rats
Kevin Manohar Salis1 and S. Ramabhimaiah21Department of Pharmacology, Vydhehi Institute of Medical Sciences, Bangalore, India.
2Navodaya Medical College, Raichur, Karnataka, India.
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin are used in the treatment of inflammation, fever and pain. They are prescribed for a variety of acute and chronic inflammatory conditions and diseases. However, NSAIDs cause gastric damage as a major adverse reaction. In this study, the anti-inflammatory activity of vegetable oils (rice bran and mustard oils) alone and in combination with indomethacin was studied using carrageenan-induced rat paw edema. The gastro-protective effect of vegetable oils was also studied using model of indomethacin induced gastric damage and compared with omeprazole. The results showed that rice bran oil significantly (p<0.001)reduced the paw edema (97.08%) and improved the anti-inflammatory effect of indomethacin in carrageenan-induced paw edema. However, mustard oil did not show any significant anti-inflammatory activity. Besides, the administration of indomethacin together with the vegetable oils did not cause a statistically significant gastric lesions. However, administration of indomethacin alone caused statistically significant gastric lesions. These results suggest that rice bran oil improved the anti-inflammatory effect of indomethacin in acute model of inflammation and rice bran and mustard oils reduced the ulcerogenic effect of indomethacin on the gastrointestinal tract when they are used together with indomethacin.
Keywords: Carrageenan inflammation; Indomethacin; gastric damage; vegetable oils Back to TOC