Self Nano Emulsifying Drug Delivery Systems for Oral Delivery of Hydrophobic Drugs
Udaya Sakthi M, Josephine Ritashinita Lobo F. and Kiran B. Uppuluri*Department of Pharmacy, School of Chemical and Biotechnology, SASTRA University, Thanjavur- 613 401, India.
Abstract: Self-emulsifying drug delivery systems (SNEDDS) are highly in quest due to their innumerable benefits like better portability, improved stability and higher drug loading, coupled with ease and economy of their production. SNEDDS are used to improve the solubility of high lipophilic drugs. SNEDDS are improving the oral bioavailability of limited water-soluble drug compounds. These SNEDDS are isotrophic mixtures of oil, surfactant, co-surfactant and drug that form oil in water emulsion in aqueous environment under gentle agitation. This paper presents an overview of the design, preparation and characterization, effects on the bioavailability of various drugs and various literature reports on diverse types of self-emulsifying formulations.
Keywords: SNEDDS; Poorly water soluble drugs; Formulation; Characterization Back to TOC