Mucoxin (Acetogenin) Reduces Proinflammatory Cytokines in Breast Cancer
Muhartono*1, Subeki2 and Rizki Hanriko11Medical Faculty, Universitas Lampung in Bandar Lampung, Indonesia.
2Department of Agricultural Technology, Agriculture Faculty, Universitas Lampung, Indonesia.
Corresponding Author E-mail: dmuhartono@gmail.com
Abstract: Mucoxin is a potential compound used as an anticancer agent. Mucoxin induced apoptosis and inhibit proliferation in T47D breast cancer cells line. This study aims to determine the effect of mucoxin on proinflammatory cytokines in breast cancer. Proinflammatorycytokines play important role in the development and metastasis of cancer cells. Breast cancer cell line MCF-7 were grouped into five groups referred to mucoxin doses assays, they are 0 ng/mL; 0,1ng/mL; 0,5 ng/mL; 1 ng/mL; 5 ng/mL with three replication of each. Mucoxin was given for 48 hours. The levels of IL 6 and TNF-α assayed using ELISA methods. The results showed mucoxin decreases IL 6 levels in all treatment doses, but was not significant. Mucoxin also decreases TNF-α levels, with a significant reduction occurring at doses of 1 ng/mL and 5 ng/mL. It is suggested that mucoxin has potent to inhibit proinflammatory cytokines that play a role in the development and metastasis of breast cancer.
Keywords: Acetogenin; IL 6; Mucoxin; MCF-7; TNF-α Back to TOC