Wound Healing Activity of Alcoholic Extract of Tamarix Aphylla L. on Animal Models
Sajid Ali1, Sarfaraz Alam1, Sarfaraz Ahmad1, Maksood Ali1, Waquar Ahsan1, Masoom Raza Siddiqui2, Salahuddin Ansari3, Shamim4 and Mohammad Daud Ali*51College of Pharmacy, Jazan University, Jazan, KSA.
2Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia, KSA.
3College of Pharmacy, Al-Dawadmi, Shaqra University, KSA.
4College of Pharmacy Teerthanker Mahaveer University Moradabad, Uttar Pradesh 244001, India.
5Department of Pharmacy, Mohammad Al-Mana college of Health Sciences, Abdulrazaq Bin Hammam Street, As Safa, Dammam, 34222, KSA.
Corresponding Author E-mail: dali.niper@gmail.com
Abstract: To evaluate the wound healing activity of ethanolic extract of Tamarix aphylla L. on animal model. Wound creation like circular excision and linear incision method were considered for this study. The various parameters were studied like DNA estimation, total protein estimation, estimation of Hexosamine and Uronic acid, estimation of lipid peroxides and antioxidant activity, Tensile Strength of tissues from incision wounds, Antioxidant activity, Antimicrobial activity, Period of epithelialization and finally TNF-a concentration in the wound tissue homogenate were estimated. The treatment groups with the extract showed significant antimicrobial activity with compare to the standard drug. Significantly, 93. 86% increase in the collagen content and significant 52% up regulation in tensile strength was observed in the treated group. 40% reduction was observed in epithelialization period of the treated wounds. The results of the current study confirm that the ethanolic extract of T. aphylla has potent wound healing capacity.
Keywords: Epithelialization Period; Tamarix Aphylla; Tensile Strength; TNF-Α; Wound Healing Back to TOC