Lung Cancers and the Roles of Natural Compounds as Potential Chemotherapeutic and Chemopreventive Agents
Omchit Surien
, Ahmad Rohi Ghazali and Siti Fathiah Masre*Biomedical Science Programme, Centre of Health and Applied Sciences, Faculty of Health Sciences, National University of Malaysia (UKM), 50300 Kuala Lumpur, Malaysia.
Corresponding Author E-mail: sitifathiah@ukm.edu.my
Abstract: Among all types of human cancers, lung cancer is one of the most common and has the highest mortality rate. Two major groups of lung cancer based on histological features are non-small cell lung cancers (NSCLCs) and small cell lung cancers (SCLCs). NSCLCs are further subdivided into few subtypes such as adenocarcinoma (AD), squamous cell carcinoma (SCC) and large cell carcinoma(LCC). Focusing on specific treatments or molecular targeted therapy for each type of lung cancers promising the better results as each subtype of lung cancers differ in genomic alterations, the cell of origin and growth pattern. Numerous studies have been done to search for the best chemotherapeutic and chemopreventive agents that can reduce the burden of lung cancer, primarily focusing on potential natural products. This review is focused on genomic alterations and current potential natural compounds as chemotherapeutic and chemoprevention agents specifically on each subtype of lung cancers.
Keywords: Chemotherapeutic; Chemoprevention; Lung Cancers; Non-Small Cell Lung Cancers; Natural Compounds; Small Cell Lung Cancer Back to TOC