Synthesis, Characterization and Hypoglycemic Activity of Cr (III) Complexes of Sulphonyl-ureas, as Oral Antidiabetics
Mohammad TawkirDepartment of Chemistry, Saifia Science College, Barkatullah University, Bhopal - 462 001, India.
Abstract: Synthesis, characterization and hypoglycemic activity of chromium(III) complexes with Gliclazide (GLC), Glibenclamide (GLB) and Glimeperide (GLM) oral antidiabetic allopathic drugs have been studied. The conductometric titration using monovariation method indicates that complexes are non-ionic and L2M type. Analytical data agrees with the molecular formulae of complexes viz., (C15H21N3O3S)2Cr·2H2O, (C23H28N3O5SCl)2Cr·2H2O, (C24H34N4O5S)2Cr·2H2O. Structure of complexes was assigned as octahedral in which ligand molecules lie horizontally joining the central chromium atom and two water molecules attached vertically with the metal. Infra-red spectral studies confirm the coordination of sulphonyl oxygen on one side and enolic oxygen from other side with metal ion, IR, Mass and 1H-NMR studies supports structure IV for the complex proposed on the basis of analytical data. Magnetic susceptibility a suggest that the complexes are diamagnetic,
Keywords: Sulphonyl Ureas complexes; Hypoglycemic activity; HPMC-5CPS pellets Back to TOC