Supplementation of Water Extract of Purple Sweet Potato (Ipomoeo Batatas L) in Improving the EEG Image, Decreasing the Seizure Frequency and Reducing the Frequency of Drugs Resistant of Focal Epilepsy in Children
I. Gusti Ngurah Made Suwarba1, Soetjiningsih1, I. Made Bakta2, I. Made Jawi3, I. Dewa Made Sukrama3, I. Wayan Putu Sutirta Yasa4 and Irawan Mangunatmadja51Department of Child Health, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia.
2Department of Internal Medicine, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia.
3Department of Pharmacology, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia.
4Department of Clinical Pathology, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia.
5Department of NeuroPediatric, Faculty of Medicine, University of Indonesia-RSCM Hospital, Jakarta-Indonesia.
Corresponding Author E-mail: suwarbangurah@yahoo.co.id
Abstract: The water extract of purple sweet potato contains of anthocyanin, a sub-class of flavonoid that has powerful antioxidant, antiinflammatory, and anticonvulsant effect. The aim of this study was to determine the effectiveness of supplementation of water extract of purple sweet potato towards recovery (remission) of drug resistant focal epilepsy (DRFE) in children with standard conventional antiepileptic medicine. It was found that the supplementation of purple sweet potato extract had a pure effect in improving all of the dependent variables, including decreased of the serum level of 8-OHdG by 1.611 pg/mL (p<0.001); decreased the serum level of IL-6 by 3.320 pg/mL (p<0.001); increased the total SOD serum level by 0.208 IU/mL (p=0.003); improved the EEG image (p=0.004); and decreased the seizure frequency at the end of the sixth week by 3.972 times (p<0.001), compared to the control. There is a significant effect on the use of supplementation of purple sweet potato extract in decreasing the serum level of 8-OHdG, decreasing the serum level of IL-6, increasing the total SOD serum level, improving the EEG image, decreasing the seizure frequency at the end of the sixth week, which at the end reducing the frequency of drugs resistant of focal epilepsy in children.
Keywords: Children; DRFE; Epilepsy; Purple Sweet Potato; Seizure Back to TOC