Anti-Inflammatory Activity of Aqueous Extract of Carica papaya Seeds in Albino Rats
Md. Zubair Ahmed and S. RamabhimalahDepartment of Pharmaology, Navodaya Medical College, Raichur - 584 103 (India).
Abstract: To study the anti-inflammatory effect of aqueous extract of Carica papaya seeds in acute, sub-acute and chronic experimental models in albino rats. The aqueous extrac tof air-dried seeds of Carica papaya was studied in arrangement-induced paw oedema in rats and the paw volume was measured plethysmometrically at 0 and 3 h after injection and compared with control and standard drug, diclofenac. The drug was subjected to cotton pellet-induced granuloma test in rats. The implanted pallets, removed 8th day were cleaned, dried and weighed. The percentage inhibition of granuloma formation was calculated in comparison to control. The drug was also investigated in formalinduced oedema model in rats. Degree of inflamation was measured plethysmometrically on day 1 and 0 and compared with control and standard drug, diclofenac. All the drug were administered orally. The aqueous extract of Carica papaya significantly (p>0.01) reduced carrageenam-induced pedal oedema (83.5%) and formalininduced pedal oedema (79.06) in rats. It also decreased formation of granulation tissue (52.55) in cotton pellet-induced granuloma in rats in comparasion to control. The aqueous extract of Carica papaya seeds showed significant anti-inflammatory action in acute, sub-acute and chronic experimental models in rats.
Keywords: Carica papaya inflammation; oedema granuloma diclofenac Back to TOC