Development of an Analytical Method for Spectrophotometric Estimation of Ketoprofen using mixed Co-solvency Approach
G. Vijayaranga Vittal, R. Deveswaran*, S. Bharath, B. V. Basavaraj and V. MadhavanM.S.Ramaiah College of Pharmacy, M.S,R.Nagar, M.S.R.I.T Post, Bangalore - 560 054 (India).
Abstract: The present study demonstrates the use of mixed co solvency in the enhancement of solubility and estimation of ketoprofen, practically water insoluble dug and thus precludes the use of organic solvents. The selected solubilizers were sodium citrate (15%), PEG 400 (8%) and polyvinyl pyrolidine (7%). Beer’s law was obeyed in the concentration range of 2-20µg/ml at wavelength of 256nm. The solubility of ketoprofen was increased by 30 folds in the mixed cos-solvents as compared to distilled water. The recovery study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed method. The low values of LOD and LOQ indicated good sensitivity of proposed method. The study proved that mixed co-solvency phenomenon is an effective technique in enhancement of aqueous solubility of poorly water soluble drugs and can be successfully employed for estimation of drugs in routine analysis of tablets.
Keywords: Mixed co-solvency; ketoprofen; sodium citrate; PEG 400; PVP Back to TOC