Effect on Crude Oil on Intestinal Motility and Histology of Illeum of Wistar Rats
Naiho Alexander Obidike

Department of Physiology Delta State University Abraka, Delta State (Nigeria).

Abstract:

ABSTRACT

Diesel exhaust is a common air pollutant made up of gases hydrocarbon and particles. This work examined the effect of liquid diesel on gastro-intestinal motility and histology of ileum.18 female wistar rats were used for the experiment and divided into three; control group A, experimental group B and experiment group C. The group A was administered with Rat Chow and Water while, the group B and group C received 10mg/kg and 15mg/kg mixture of diesel and water respectively for a period of 21 days. The animals were weighed and sacrificed after an overnight fast and administration of activated charcoal meal. Results show it was observed that there was a non-significant (p>0.05) reduction in weight of the experimental groups compared to that of the control group. Group B (10mg/kg) and group C (15mg/kg) showed significant (p<0.05) increased in intestinal motility but between the two there was no significant (p>0.05) difference. In conclusion liquid diesel caused reduced weight and dose dependent increased GIT motility and adverse structural changes in the histology of the ileum. It is therefore advised that individuals should avoid ingestion of water contaminated with diesel.

Keywords: Crude oil; Ileum; motility; Diesel

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