Comparative Evaluation of Releasing Rate of Nifedipine in S.R. Products from Indian Market by Spectrophotometry
Bincy Thomas¹, V. V. Pande², A. R.Tekade³ and K. V. Shastri4¹Departemnt of Pharmaceutical Analysis, Allana College of Pharmacy, Pune.
²Department of Pharmaceutical Analysis, Jayawantrao Sawant College of Pharmacy and Research, Hadapsar, Pune.
³Departement of Pharmacognosy and Phytochemistry Vivekanand Education Society’s College of Pharmacy Chembur (E), Mumbai.
4Department of Pharmaceutics, R.C. Patel College of Pharmacy, Shirpur.
Abstract: Nifedipine, a calcium channel blocker inhibits the movement of calcium ions across the membranes of cardiac and arterial muscle cells is mainly indicated in angina pectoris, hypertension, raynaud’s phenomenon, myocardial infarction and asthma. It is recommended to administer Nifidipine as modified release dosage form in order to avoid fluctuations in blood vessels. There are several brands of Nifedipine available in the Indian market. Two of such brands of Nifedipine BRAND A and BRAND B were procured from the Indian market and were subjected to spectrophotometric analysis by comparing with the control in order to determine their dissolution patterns. The results indicated that not all the brands of Nifedipine exhibit the same therapeutic effect as there was variation in the release of the active ingredient at the various time intervals and at different levels of pH.
Keywords: Nifedipine sustained release; spectrophotometery; absorbance Back to TOC