Screening the Pharmacological Activity of Cerium Oxide Nanoparticles In vitro
S. K. Aminabee¹*, M. C. Prabhakara¹, R. G. S. V. Prasad¹ and A. Lakshmana Rao²¹Shri Vishnu College of Pharmacy, Bhimavaram - 534 202, A.P. India.
²V. V. Institute of Pharmaceutical Sciences, Gudlavalleru - 521 356 India.
Abstract: In microbiological and clinical studies, cerium oxide (CeO2) nanoparticles have been shown to protect cells in culture from lethal stress. Cardiac-specific expression of monocyte chemo-attractant protein-1 (MCP-1) in mice causes ischemic cardiomyopathy associated with activation of endoplasmic reticulum (ER) stress. CeO2 nanoparticles protect against the progression of cardiac dysfunction and remodeling by attenuation of myocardial oxidative stress, ER stress and inflammatory processes probably through their auto regenerative antioxidant properties. In the present study we have examined the effect of cerium oxide (CeO2) nanoparticles in vitro. For this purpose we have choosen frog as an experimental animal and the tissue was frog isolated heart. Cerium oxide (CeO2) nanoparticles elicited dose-dependent cardiac depressant activity. Atropine (ATP) a muscarinic blocker could not antagonize the effects of cerium oxide nanoparticles which indicate that the activities are not mediated through muscarinic receptors.
Keywords: Cerium oxide; Heart rate; Cardiac output Back to TOC