Role of Caspase-3 as Risk Factors of Premature Rupture of Membranes
Ketut Surya Negara1
, Ketut Suwiyoga1, Komang Arijana2 and Ketut Tunas31Department of Obstetrics and Gynecology, Udayana University Sanglah Hospital Bali, Indonesia.
2Biomedic Laboratory Medical Faculty Udayana University Bali, Indonesia.
3Department of Public Health Dhyana Pura University Bali, Indonesia.
Corresponding Author E-mail: tutsuryanegara@gmail.com
Abstract: Premature rupture of membranes (PROM) is one of the problems in the field of obstetrics, related to the prevalence, prematurity, perinatal morbidity and mortality. Causes of PROM are multifactorial and its mechanisms are not yet clear. The weakening of the membranes is suspected as a result of biochemical processes that result in remodeling and apoptosis, as well as membranes stretching. Apoptosis plays an integrated role in the occurrence of premature rupture of membranes.To investigation the role of caspase-3 in premature rupture of membranes.A case-control study with PROM as a case, and non-PROM as a control at 20-42 weeks gestation. Amniotic tissue was taken after delivery of the placenta. Immunohistochemical examination of Caspase-3 was done at Integrated Lab.Biomedic Medical Faculty of Udayana University in Bali.The study was conducted on 36 cases of PROM and 37 cases non PROM. There was no characteristic difference between the case and control groups (p>0.05). The expression of positive caspase-3 is a risk factor of PROM of 7.3 times (OR = 7.31; CI 95% = 2.64 to 20.22; p = 0.001). Caspase-3 gene expression was more in the group of PROM. Caspase-3 expression is a risk factor for premature rupture of membranes.
Keywords: Caspase-3 PROM; Back to TOC