In Vitro Evaluation of Cytotoxic Properties of Piperic Acid
Nitya Rudraraju1,2, Animisha Mokkapati1, Radhakrishna Nagumantri1, Chinna Babu Pydi1, Ramakrishna Chintala3 and Satyanarayana Rentala1

1Department of Biotechnology, Institute of Technology, GITAM University, Gandhi Nagar, Visakhapatnam 530 045 Indai.

2School of Engineering, Boston University, Massachusetts USA.

3GITAM Institute of Science, GITAM University, Gandhi Nagar, Visakhapatnam 530 045.

Corresponding Author E-mail: dr.satya@gmail.com

Abstract: A daily diet rich in spices may offer protection against cancer and other illnesses. This may be reason, why Indians suffer lower cases of many cancers. One of the most widely traded spices in the world, Piperine, the main alkaloid from black pepper has been shown to substantially increase the bioavailability of the nutrients in foods and supplements. Piperic acid is a chemical obtained by the hydrolysis of the alkaloid piperine from black pepper, followed by acidification of the corresponding salt. The cytotoxic effects of piperic acid are hither to unknown. In this paper, the cytotoxic effects of piperic acid in prostate cancer cells (PC-3) and breast cancer cells (MDA-MB-231) were studied. The drug treatment experiments clearly indicated that maximum cytotoxicity was achieved at 48 hours and at 100µM concentration of piperic acid in both the cell lines.

Keywords: Piperic acid; Cytotoxicity; Prostate cancer cell lines; Breast cancer cell lines and Mononuclear cells

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