Synthesis of some Fluorinated Phosphonium Iodide Derivatives; Study of their Biological Antibacterial Activities and the Effect of Synergy of these Compounds with Penicillin-G and Penicillin-V
Elias Babarbi, Maammar Haffas, Messaoud Guerri and Lakhdar Sekhri*Department of Chemistry, Faculty of Sciences, University of Kasdi Merbah, Ouargla - 300 00 (Algeria).
Abstract: Tris (pentafluorophenyl) phosphine, bis (pentafuorophenyl) phenylphosphine, tris (4-fluorophenyl) phosphine and triphenylphosphine are readily reacted with an excess of methyl iodide in chloroform at boiling point to afford respectively phosphonium salts of methyl tris (pentafluorophenyl)phosphonium iodide, methyl bis (pentafuorophenyl)phenylphosphonium iodide, methyl tris (4-fluorophenyl) phosphonium iodide and methyl triphenylphosphonium iodide. These phosphonium salts showed significant activity against all the bacteria tested, Escherichia Coli, Protius, Staphylococcus Aureus and Pseudomonas. The combination of these phosphonium salts with the penicillin G or V gives a synergistic effect.
Keywords: (pentafluorophenyl); phosphine; synergistic effect; bacteria; penicillin-G; V Back to TOC