The Role of the VEGF, KGF, EGF, and TGF-Β1Growth factors in the Pathogenesis of Telogen Effluvium in Women
A. A. Kubanov1, 2, Yu. A. Gallyamova1, O. A. Korableva2 and P. A. Kalinina2,11State Research Center of Dermatovenereology and Cosmetology Ministry of Healthcare of the Russian Federation Korolenko street, Moscow, 107076, Russia.
2Russian Medical Academy of Postgraduate Studies of the Ministry of Healthcare of the Russian Federation building 1, Barrikadnaya street, Moscow, Russia.
Abstract: In the recent time, several growth factors were revealed that appear to control the development and the cycle of a hair follicle. However, the contribution of these factors into the pathogenesis of alopecia keeps being poorly studied. So far, all the studies have experimental nature, most of them conducted in vitro or on animal models. Thus, the role of the growth factors in the pathogenesis of different types of alopecia and their impact of the severity of this pathology remains unclear. The purpose of this study was to investigate the role of the VEGF, KGF, EGF, and TGF-β1 growth factors in the development of telogen effluvium in women. The study involved 30 female patients with telogen effluvium and 8 healthy volunteers. All the patients were examined, medical history was collected, trichoscopy and phototrichogram tests were performed. From every patient, a sample of scalp was taken by punch biopsy (4mm), which was analyzed by the standard immunohistochemical study. We discovered changes in the expression of the growth factors in women with telogen effluvium in comparison with healthy volunteers. Our results showed that all the studied growth factors (VEGF, KGF, EGF, TGF-β1) contribute to the development of telogen effluvium; VEGF has the biggest impact and EGF has the lowest impact on hair loss.
Keywords: Growth factors; hair loss; telogen effluvium; hair follicle; hair cycle; immunohistochemical research; VEGF; KGF; EGF; TGF-β1 Back to TOC