Biochemical Changes Followed Experimental Respiratory Distress by Benzene Vapours
Abdel Maksoud H. A1, Mahfouz M. K1, Omnia M. A1, Abdullah M. H2, Eltabey M. E1 and Mohamed G. Elharrif3  

1Department of Biochemisry, Benha University, Egypt.

2Department of Biochemisry, 6th October University, Egypt.

3Department of Basic Medical Sciences, Shaqra university, KSA, Kingdom of Saudi Arabia.

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Abstract: Monitoring of exposure to chemical matters is seriously needed  for evaluating health hazards resulted from its inhalation. The present study was carried out to determine the biochemical, immunological and oxidative stress parameters as well as the possible histological effects of exposure to benzene vapours in male albino rats. Results indicated that; Benzene vapours exposure  induced significant increasing in Myeloperoxidase (MPO) enzyme levels. This goes with marked immunologic changes presented by decreases in immunoglobulins; IgA and IgG, along with increases in levels of IgM and IgE. Also, Malondialdehyde (MDA) levels were significantly increased. Meanwhile, reduction in different biochemical parameters including; Superoxide Dismutase  (SOD), Catalase (CAT) levels and Glutathione (GSH) content. Lung sections taken showed; Thickening of alveolar septa with chronic inflammation and /or fibrosis, Congested vessels/thick walled vessels and Peri-bronchiolar fibrosis. Hence, the study concluded that; prolonged benzene (BNZ) vapours exposure lead to biochemical, immune disterbance and histopathological changes  probably through potentiating oxidative stress and inflammation pathways.

Keywords: Benzene Exposure; Inflammatory Pathways; Oxidative Stress

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