Comparison of Bone Mineral Density with Biochemical Parameters and Prevalence of Osteopenia and Osteoporosis in South Indian Population
Modagan1, Dr. Santhi Silambanan1, Dr. P. Gopinath Menonand Dr. P. Arunalatha3

1Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai, India.

2Department of Orthopaedics, Sri Ramachandra Medical College and Research Institute, Chennai, India.

3Department of Pathology, Stanly Medical College, Chennai, India.

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Abstract: Osteoporosis is identifying based on the bone mineral density (BMD). The bone mineral mass or BMD exposes the amount of minerals present in a particular region of bone tissue. BMD measurement by DEXA is consideredas gold standard, but it is very expensive. The people of developing countriesare not interested to check BMD until the occurrence offracture. Therefore present study focusing any association of routine biochemical markers with BMD in osteoporosis and also planning to identify disease distribution status in south India. We examined 773 participants BMD by DEXA scan and grouped into three, Group I (Normal bone mass, n=237), group II (Osteopenia, n=345) and group III (Osteoporosis, n=191). The serum calcium, phosphorous and alkaline phosphatase (ALP) were estimated by automated chemistry analyzer., and Serum 25(OH) vitamin D was analyzed by immunoassay system analyser. The prevalence of normal BMD, osteopenia and osteoporosis was 30.7%, 44.6%and 24.7% respectively.Between 60 and 69 years aged men having more prevalence of osteopenia and in women 50 to 59 years of age. While osteoporosis in men 50 to 59 years and in women’s were 60 to 69 years of age. The serum calcium, ALP and 25 (OH) vitamin D levels were statistically significant (p< 0.001) between the three groups.The higher percentage of low bone mineral density (osteopenia) is the alarming signalto the bone health and this could be continued leads to osteoporosis, which affects the quality of life. This study suggests to determining BMD along with biochemical markers are useful to identify osteoporosis in earlier stage. Therefore routine screening of BMD may prevent the risk of osteoporosis.

Keywords: BMD; DEXA; Fractures; Osteopenia; Osteoporosis; South Indian

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