Evaluation of Biological Activity Exerted by an Aza-Bicyclo-Carboxylic Acid Derivative Using an Ischemia-Reperfusion Injury ModelFigueroa-Valverde Lauro1,, Rosas-Nexticapa Marcela2, Mateu-Armand Virginia2, Herrera-Meza Socorro3, Díaz-Cedillo Francisco4, García-Cervera Elodia1, Pool-Gómez Eduardo1, García-Martínez Rolando1, Cauich-Carrillo Regina1, Euan-Hau Saidy1, Parra-Galindo Perla2
1Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp.,México.
2Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México.
3Instituto de Investigaciones Psicológicas, Universidad Veracruzana. Av. Dr. Luis Castelazo Ayala s/n Col Industrial Animas. C.P. 91190, Xalapa, Veracruz, México.
4 Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México.
Corresponding Author E-Mail: firstname.lastname@example.org
Abstract: The main objective of this study was to evaluate the biological activity of a new compound (derived from aza-bicyclo-carboxylic acid) against heart failure caused by the ischemia- reperfusion phenomenon. In addition, to characterize de molecular mechanism involved in the effect exerted by aza-bicyclo-carboxylic acid against infarction area, some drugs such as prazosin, metoprolol, propanolol, tamoxifen, flutamide, finasteride, nifedipine, levosimedan, adenosine, rolofylline, isoproterenol and the compound ZM-241385 were used as pharmacological tools. The data found indicated that biological activity induced by compound 3 on infarction area only was similar at effect exerted by adenosine; however, the effect produced by compound 3 was blocked with of rolofylline. Other data showed that the biological activity of compound 3 decreases the cAMP levels in a time-dependent manner. In conclusion, the results indicate that compound 3 can produce a cardioprotective effect against myocardial ischemia-reperfusion injury translated as a decrease on infarction area; this phenomenon involves A1-adenosine receptor activation and, as a result may cause changes in cAMP levels.Keywords: Adenosine; Camp; Ischemia; Reperfusion; Rolofylline Back to TOC