Mathematical Modeling for Pharmacokinetic Predictions from Controlled Drug Release NanoSystems: A Comparative Parametric Study
Ziyad S. Haidar

1BioMAT’X, Facultad de Odontología, Universidad de los Andes, Santiago, Chile.

2CIIB, Facultad de Medicina, Universidad de los Andes, Santiago, Chile.

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Abstract: In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the χ2 minimization method, is employed concluding that the Korsmeyer-Peppas model provides the best-fit in all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.

Keywords: Drug dissolution; Least squares method; Mathematical modelling; Model comparison; Release kinetics; Statistical analysis

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