Mathematical Modeling for Pharmacokinetic Predictions from Controlled Drug Release NanoSystems: A Comparative Parametric StudyZiyad S. Haidar
1BioMAT’X, Facultad de Odontología, Universidad de los Andes, Santiago, Chile.
2CIIB, Facultad de Medicina, Universidad de los Andes, Santiago, Chile.
Corresponding Author E-Mail: email@example.com
Abstract: In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the χ2 minimization method, is employed concluding that the Korsmeyer-Peppas model provides the best-ﬁt in all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.Keywords: Drug dissolution; Least squares method; Mathematical modelling; Model comparison; Release kinetics; Statistical analysis Back to TOC