Preparation, Characterization and anti-cancer activity of a new Bis[(Z)-N-(naphthalene-1-yl methylene) aceto hydrazide] Mn(II) ComplexShahriar Ghammamy
Department of Chemistry, Faculty of Science, Islamic Azad University, Malard Branch, Malard (Iran).
Abstract: Metal-hydrazide of the ligand Bis[(Z)-N-(naphthalene-1-yl methylene) aceto hydrazide] that was abbreviated as NNMAH. It was synthesized and identified and was prepared by the reaction of Bis [(E)-N-(3-nitrobenzylidene) isonicotino hydrazide] and Mn(NO3)2 in hexane with Diethyl ether. Characterization of the ligand and its complex were made by microanalyses, FT-IR, 1HNMR and UV–Visible spectroscopies. The biological property such as antitumor of this complex was studied. This new complex showed excellent anti-tumor activity against two kind of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.Keywords: Manganese (II); Bis[(Z)-N-(naphthalene-1-yl methylene) aceto hydrazide]; Praparation Back to TOC