Pathological Risk Factor Profile for Enucleated Retinoblastoma at Sanglah General Hospital
Putu Yuliawati1 and Ni Putu Ekawati2  

1Department of Ophthalmology, Faculty of Medicine Udayana University, Sanglah General Hospital, Denpasar, Indonesia.

2Department of Pathology Anatomy, Faculty of Medicine Udayana University, Sanglah General Hospital, Denpasar, Indonesia

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Abstract: Retinoblastoma is a primary intraocular tumor on childhood. It has a good prognosis with early detection. Aim of this study is to know Pathological Risk Factors (PRF) profile of enucleated retinoblastoma at Sanglah General Hospital. This study is an observational retrospective study based on patient’s medical record and pathological examination. Twenty patients were included in this study, 50% were female and 50% male within age ranging from 7 month – 12 years old. Unilateral retinoblastoma was found in 18 patients (90.5%), bilateral retinoblastoma was found in 2 patients (9.5%). Majority PRF profile found that cancer cell invasions was 60% choroid infiltration and 45% of anterior segment invasion, 60% of optic nerve infiltration, and 50.1% scleral invasion. Tumor cell aggregation showed 61.9% poorly differentiated malignant cells. None of the patients had family history of retinoblastoma. This study revealed optic nerve and choroid invasion were the major PRF found in retinoblastoma, but there is a significant association between scleral infiltration and tumor cell differentiation (p = 0.025). There was no statistical difference of PRF based on age, gender, and laterality.

Keywords: Enucleated Retinoblastoma; Pathological Risk Factors; Retinoblastoma; Tumor Differentiation

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