Influence of Energy Drinks on Pharmacokinetic Parameters of Sildenafil in Rats
Mohammad Abdulla1, Eyad Mallah1, Wael Abu Dayyih1, Walid Abu Rayyan1, Feras Darwish El-Hajji2, Mona Bustami1, Kenza Mansour1, Israa Al-Ani3, Nisreen Seder4 and Tawfiq Arafat1

1Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.

2Faculty of Pharmacy and Medical Sciences, Applied Science University, Amman, Jordan.

3Faculty of Pharmacy and Medical Silences, Al-Ahliyya Amman University, Jordan.

4School of Biomedical Science, Faculty of Health Sciences, University Sultan Zainal Abidin, 21300 Kuala Nerus, Terengganu, Malaysia.

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Both sildenafil and RED BULL®(energy drink) are claimed to boost up energy.RED BULL®, one of the most commonly used energy drinks and its easily and widely available for daily use, the idea of this research work had arisen from observations about the concomitant use of sildenafil with RED BULL® by men seeking for better sexual performance. To study the effect of RED BULL® on the pharmacokinetic profile of sildenafil by using HPLC.The pharmacokinetic parameters (Cmax, Tmax and AUC) were determined in 10 rats following oral administration of 0.57 mg/ml sildenafil with and without RED BULL® in crossover design, to achieve this purpose,simple, rapid and accurate method for validation and determination of sildenafil in rat plasma in the presence of RED BULL® has been developed. This was performed using High-Performance Liquid Chromatography- Ultra Violet (HPLC-UV). The pharmacokinetic data showed that sildenafil plasma level was lower when combined with RED BULL® According to the results obtained, maximum concentration (Cmax) for sildenafil alone was (162.05 ng/ml) after 0.5 hours of administration. The Cmax decreased to (44.68 ng/ml) after 0.5 hoursof administration RED BULL® concomitantly with sildenafil which showed a significant effect on sildenafil plasma level (P<0.001). The area under the curve (AUC) decreased significantly from (370.53 ng/ml*hr) for sildenafil alone to (87.74 ng/ml*hr) when combined with RED BULL®. RED BULL® can alter sildenafil pharmacokinetic if they were taken together.

Keywords: Drug Interaction; Energy Drinks; Pharmacokinetic; Sildenafil; Validation

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