Biotechnological Transformation of Artemisinin: Toward an Effective Anti-Malaria Drug
Muhammad Nor Omar¹, Nor Hazwani M. Hasali¹, Naik T. Khan², Syed Faraz Moin² and Helmi Y. Alfarra¹

1Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, (Malaysia). ²International Center for Chemical and Biological Sciences, University of Karachi, Karachi (Pakistan).

Abstract: In recent years, artemisinin (1) has remained an effective drug to treat malaria. Numerous approaches have been adapted to increase the efficacy of (1) against antibiotic resistant malarial parasite. Microbial biotransformation of (1) has been used recently to produce promising derivatives of (1) on a large scale with low costs. During the last decade several biotransformation studies on (1), by using microorganisms, have been reported. This literature review focuses on the most recent microbial transformation studies on artemisinin and its derivatives.

Keywords: Artemisinin; Malaria; Biotransformation; Microorganisms; Hydroxylation

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