Sperm Na+ K+-ATPase and Ca2+-ATPase Activities: A Potential Predictive Parameter of Sperm Motility Disorder in Infertile Men
Silvia W Lestari1,4, Manggiasih D. Larasati2, Indra G. Mansur1,4 and Ria Margiana3,4  

1Department of Medical Biology, Faculty of Medicine Universitas Indonesia.

2Master Program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia.

3Department of Anatomy, Faculty of Medicine Universitas Indonesia.

4The Indonesian Reproductive Medicine Research and Training Center, Ina-Repromed.

Corresponding Author E-mail: finallysilvia@gmail.com

Abstract: Current highlight on the etiology of male infertility is a disorder in sperm motility  which is caused by ion homeostasis imbalance involving the ubiquitous multifunctional transmembrane protein, Na+K+-ATPase and Ca2+-ATPase enzymes. The emphasis of this review is evaluating the use of sperm’s Na+K+-ATPase and Ca2+ATPase activity as predictive parameters of sperm motility disorder. To this purpose, a computerized search of PubMed database was performed and obtained data were reviewed in this paper. The retrieved studies were laboratory experiments involving human and mice sperm as the subjects. Na+ K+-ATPase and Ca2+-ATPase play an essential role in sperm motility by controlling ion homeostasis. Na+ K+-ATPase maintains the intracellular pH by transporting 3 Na+ out and 2 K+ into the cell, whereas Ca2+-ATPase extrudes Ca2+ from the cell. The impairment of these enzymes and its isoforms, Na+ K+-ATPase α4 and PMCA4 expression were proved to decrease sperm motility.

Keywords: Male Infertility; Sperm Motility; Na+ K+-ATPase; Ca2+ATPase

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