Administration of Curcuma longa Extract Topically does not Accelerate Skin Excision Wound Closure in Alloxan-induced Diabetic Mice Model
Afiat Berbudi1, Ulfah Hasna Hasibah2, Ahmad Faried3, Almahitta C. Putri4 and M. Ersyad Hamda1

1Department of Microbiology and Parasitology, Padjadjaran University, Bandung, Indonesia.

2Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

3Department of Neurosurgery, Faculty of Medicine, Padjadjaran University/Hasan Sadikin General Hospital, Bandung, Indonesia.

4Department of Surgery, Faculty of Medicine, Padjadjaran University, Indonesia.

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Abstract: The aim of this study was to know whether the administration of turmeric extract gel topically can accelerate diabetic wound healing. This studywas an experimental analytical research in vivo laboratory using quantitative method. The subjects of this study were alloxan-induced diabetic mice model. The skin excision wounds were made on the back of the mice. The subjects were divided into 3, i.e. the group that given 1) blank gel (control) 2) Curcuma longa extract gel 3) nanocurcumin gel, topically on wound once daily for 24 days. There was a tendency of nanocurcumin gel to accelerate wound closure on day 3 and 9 of observation (p=0.459 and p=0.317). Whereas, Curcuma longa gel had tendency to accelerate wound closure on day 6 and 12 (p=0.429 and p=0.485). On day 15 until 24, there was no tendency of nanocurcumin and Curcuma longa gels to accelerate wound closure. However, overall there was no differences in the rate of wound closure in all three groups as analyzed by ANOVA, thus represented by the area under curve (AUC) (p=0.521). Despite there is a tendency of nanocurcumin and Curcuma longa gels to accelerate the wound closure in the early stages of wound healing, administration of Curcuma longa and nanocurcumin gels topically do not accelerate skin excision wound closure in alloxan-induced diabetic mice model.

Keywords: Curcuma Longa Extract Gel; Diabetes Mice Model; Diabetic Wound; Nanocurcumin Gel; The Rate of Wound Closure

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