Maternal Beta Hcg Levels Day 12 After Embryo Transfer to Predict Pregnancy Outcome in In-Vitro Fertilization Clinic Prima Medika, Denpasar Bali Indonesia
Ida Bagus Made Kartha1, I. Made Mahadinata Putra2, Ida Ayu Indira Mandini2 and I. Made Pande Dwipayana3

1Ob/gyn specialized, Reproductive Endocrinology and Infertility Consultant doctors in In-vitro Fertilization Clinic, Prima Medika Hospital, Denpasar, Bali, Indonesia.

2Ob/gyn specialized doctors, in In-vitro Fertilization Clinic, Prima Medika Hospital Denpasar, Bali, Indonesia.

3Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.

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Abstract: Many methods to predict the outcome of pregnancies achieved after assisted reproductive technology (ART) has been tested. Several serum markers have been studied in relation to pregnancy outcomes, such as β-subunit of human chorionic gonadotropin (β-hCG), estradiol, progesterone, cancer antigen 125 (Ca-125), activins, and inhibin. Among them, β-hCG has been proven that the most predictive factor. Prediction of pregnancy outcome is important in an assisted reproductive technology program. Pregnancy obtained through IVF with or without ICSI have a higher risk of obstetric and perinatal complications compared with spontaneous pregnancies. To determine the clinical value of maternal serum ß-hCG twelfth days after the embryo transfer and to predict pregnancy outcome. The method used was a retrospective study, in which the data was obtained from women undergoing IVF Clinic IVF Prima Medika Hospital Denpasar from January to December 2015. The non-viable pregnancy is defined as a biochemical pregnancy, ectopic pregnancy and miscarriage. Ongoing pregnancy is defined as a single pregnancy and multiple pregnancies, which reached more than a gestational age of 12 weeks. Serum ß-hCG levels measured on the twelfth day after ovum pick up (OPU) and compared between the two groups Twelve days after embryo transfer, the mean levels of β-hCG in ongoing pregnancy group (419.7 ± 232.9 mIU/ml) was significantly higher than the group of non-viable pregnancies (44.8 ± 72.9 mIU/ml) (p < 0.005). In multiple pregnancies, the levels of β-hCG in multiple pregnancies (683.3 ± 194.4 mIU/ml) were significantly higher than singleton pregnancies (272.7 ± 155.0 mIU/ml) (p < 0.005). Levels of maternal serum β-hCG on the twelfth day after the embryo transfer has a good predictive value for assessing the clinical pregnancy outcomes in IVF program and helps to plan the subsequent follow-up.

Keywords: levels of beta hCG day 12; Embryo Transfer; Prediction of Pregnancy Outcome

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