Diallyl Disulfide (DADS) Retards the Growth of Breast Cancer Cells in Vitro and in Vivo Through Apoptosis Induction
Sujatha P, Preethi G. Anantharaju, Prashanthkumar M. Veeresh, Sumit Dey, Venugopal Reddy Bovilla and Subba Rao V. Madhunapantula

Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), Department of Biochemistry, JSS Medical College, Jagadguru Sri Shivarathreeshwara University, Mysuru - 570 015, Karnataka, India.

Corresponding Author E-mail: mvsstsubbarao@jssuni.edu.in

Abstract: Diallyl disulfide (DADS) is sulfur containing anti-cancer agent derived from garlic.  Several in vitro studies have demonstrated the ability of DADS to inhibit the growth of cancer cells.  However, only few studies have tested the ability of DADS to retard the development of tumor cells in animal models.  Therefore, in this study we have measured the anti-tumor efficacy of DADS using well-established EAC tumor model representing a liquid-tumor.  Analysis of the data showed a significant decrease in tumor growth as evidenced by a significant reduction in animal body weight in liquid tumor model.  Mechanistically, DADS induced apoptosis by promoting caspase-3 expression and preventing the oxidative degradation of anti-tumor proteins such as p53 by upregulating antioxidant enzymes NQO1 and SOD; and reducing agents such as GSH.  In summary, DADS appears to be a potential anti-cancer agent for considering it as a monotherapy or for selecting it as a component drug in the combination trials.

Keywords: Diallyl Disulfide; EAC Model; Breast Cancer; Tumor Growth; Garlic

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