Ozone Therapy in the Comprehensive Treatment of Diabetic Foot Syndrome
Aslan Alekseevich Teuvov1, Arthur Muzkharbievich Baziev2, Zarema Nuriydinovna Lovpache1, Irina Sergeevna Teunikova1 and Sergey Mikhailovich Chudopal2

1Department of General Surgery, Medical Faculty, H.M. Berbekov Kabardino-Balkaria State University,  Nalchik, Russia.

2Department of Nervous Diseases, Neurology and Psychiatry, Medical Faculty, H.M. Berbekov Kabardino-Balkaria State University, Nalchik, Russia.

Corresponding Author E-mail: ateuvov@bk.ru

Abstract: Diabetes mellitus (DM) is often complicated by the development of purulent-necrotic lesions of the lower limbs, leading not only to early disability due to limb amputation, but also shortening the life span. The Diabetic Foot Syndrome (DFS) is a pathological state of feet in diabetes mellitus, which occurs against the background of impaired peripheral nerves, vessels, skin, soft tissues, bones and joints and is accompanied by destructive and purulent necrotic processes. DFS is observed in various forms in 20-80% of patients with diabetes and increases the risk of gangrene of the lower extremities by 20 times. And amputation of the lower limbs is performed to these patients by 15-20 times more often than in people without diabetes. The objective of the study was to evaluate the effectiveness of applying ozonated solutions in the comprehensive treatment of diabetic foot syndrome. Methods of research: all patients are divided into 2 groups. The main clinical trial group included 17 patients with DM, who were admitted in the period from January to December 2016 and had DFS developed (3-5 severity class according to F. Wagner’s classification). Clinical, hematological, bacteriological, cytological studies were performed at admission before the beginning of treatment and on the 1-3-5-7-10th postoperative day. Data from medical records of 20 patients admitted in the same period of 2015 were the subjects of the study as a control group. The control group received traditional treatment. In the main group, traditional treatment was supplemented with sessions of topical and general ozone therapy. The treatment results of 37 patients with diabetes having DFS developed were analyzed; the outcomes and prospects for the development of ozone therapy of this pathology in purulent surgery were evaluated. In the main group a rapid transition from inflammatory-degenerative processes to regenerative ones and fast complete elimination of microbial flora were observed. On the 3rd-5th day, the patients of the main group showed normalization of Erythrocyte Sedimentation Rate (ESR) parameters and total leukocyte count, decrease in the content of stab and segmented leucocytes, increase in the number of lymphocytes and monocytes, a decrease in the number of bed-days as compared to the control group. Our studies have demonstrated that supplementing the comprehensive treatment of patients having acute purulent surgical diseases with intravenous and topical ozone-containing medications exerted a pronounced therapeutic and economic effect.

Keywords: Ozone Therapy; Diabetic Foot Syndrome; Purulent Surgery

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