The Effect of Noni Leaves Extract (Morinda citrifolia L) on Wound Healing Percentage of Traumatic Ulser in Oral Mucosa of Wistar Rats (Rattus norvegicus) by in Vivo
Sri Rezeki1, Sunnati2 and Nadia Vidirachmilla1

1Department of Oral Medicine, Faculty of Dentistry, Universitas Syiah Kuala, Banda Aceh- Indonesia.

2Department of Periodontology, Faculty of Dentistry, Universitas Syiah Kuala, Banda Aceh- Indonesia.

Abstract: Traumatic ulser is a lesion in oral mucosa caused by trauma. Traumatic  ulcer resulting pain can disturb activities and metabolism. Noni leaves (Morinda citrifolia L) contain flavonoid, saponin, and tannin as anti-inflamatory, anti-bacterial, and antioxidant to accelerate healing process.  This research aimed to determine the effect of Morinda citrifolia L leaves extract on healing percentage of traumatic ulcer in oral mucosa. Ulcer was made by put hot burnisher on lower labial mucosa of twelve Rattus norvegicus for a second. They were divided into three groups. First group was given Morinda citrifolia L leaves extract, control group were given triamcinolone acetonide 0,1% and aquades. The research was performed for 10 days by measuring ulcer diameter and applicating extract. Based on Independent-Sampels T Test showed Morinda citrifolia L leaves extract has no significant effect on healing percentage compared to control groups with p = 0.18 and 0.694 (p > 0.05), recovery day for treat group was eighth day and for each control groups were tenth day. Morinda citrifolia L leaves extract has no significant effect on wound healing percentage of traumatic ulcer compare to positive control and negative control.

Keywords: Morinda citrifolia leaves extracts; traumatic ulcer; oral mucosa

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