Hemoglobin, Vitamin D, and Lipids in Subclinical Hypothyroid Patients – Do the Anti -Thyroid Autoantibodies Titer Matters?
Jaseem T1, Anupama Hegde1, Chakrapani M2 and Sathish Rao2

1Department of Biochemistry, Kasturba Medical College, Manipal University, Mangaluru, India.

2Department of Internal Medicine,  Kasturba Medical College, Manipal University, Mangaluru, India.

Corresponding Author E-mail: anupama.hegde@manipal.edu

Abstract: Hashimoto's thyroiditis, the commonest cause of hypothyroidism has been proposed as a risk factor for atherosclerosis independent of thyroid function. The aim of this study was to investigate whether Hashimoto's thyroiditis validated by their anti-TPO positivity have any effect on hyperlipidemia, Hemoglobin, vitamin D independent of thyroid function in newly diagnosed subclinical hypothyroid patients (SCH) subjects with TSH < 10µIU/ml. 40 newly diagnosed SCH and 40 healthy euthyroid controls were included in this study. Based on anti-TPO status, the SCH subjects was divided into TPO positive and negative groups. Serum lipid, hemoglobin and vitamin D levels were determined and compared between among the TPO positive and negative SCH subjects. Subjects with and without anti-TPO had significant differences in levels of low-density lipoprotein, total cholesterol, and nonHDL cholesterol. In correlation analysis, anti-TPO showed statistically significant association with Hb, LDL and vitamin D. Subclinical hypothyroidism with thyroid autoimmunity is associated with a marginal decrease in hemoglobin and elevation in LDL. Whether this holds, any bearing on promoting cardiovascular risk needs to be considered further

Keywords: Anti -Thyroid Autoantibodies; Hemoglobin; Lipids; Subclinical Hypothyroidism; Vitamin D

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