Genetic Association of KCNE1G38S Polymorphism in Postoperative Atrial Fibrillation of North Indian Population: A Case-Control Study

Surabhi Yadav1,2, Salman Akhtar1, Surendra K Agarwal2, Gauranga Majumdar2 and Suman Vimal2

1Department of Bioengineering,Integral University, Lucknow, India.

2Department of Cardiovascular and Thoracic surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

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Abstract: Atrial fibrillation (AF) is an arrhythmia which also occurs after the cardiac surgery. Apart from clinical factors some genetic factors are also involved. To know whether a genetic variant has any role or not, this study has been designed in the North Indian patients. An ion-channel gene KCNE1G38S (rs1805127) was selected to investigate its association between genetic variant and postoperative AF. The study included age and sex matched 78 postoperated-AF rhythm patients as cases and 99 postoperated-patients as controls with sinus rhythm admittedin Cardiovascular and Thoracic Surgery Department of SGPGIMS, Lucknow. The SNP detection of KCNE1G38S was geno typed by using the polymerase chain reaction based restriction fragment length polymorphism method. The geno type frequencies of the AA, AG and GG  were19.20%, 56.40%, and 24.40%, respectively, in cases, whereas in controls had frequencies of 23.20%, 56.60% and 20.20% respectively. The observed frequencies were almost similar in cases and controls. The chi-square results were not statistically significant (χ2=0.668, p=0.716) and the frequency of G allele between cases and controls did not vary (52.56% vs. 54.31%). In multivariate analyses, the KCNE1G38S variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors and the odds ratio for case was 1.272 (95 % CI: 0.594–2.726, p = 0.389). The study revealed that there is no association of AF with the genetic variant ofion channel gene KCNE1G38S in the North Indian population.

Keywords: Atrial fibrillation; cardiac surgery; KCNE1G38S; RFLP-SNP;  genotyping

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