Evaluation of Antidiabetic Activity of Aqueous and Ethanolic Extracts of Leaves of Chloroxylon Swietenia in Streptozotocin (Stz) Induced Diabetes in Albino Rats
S. L .D. V. Ramana Murty Kadali1, M. C. Das2, R. Vijayaraghavan3 and M. Vijay Kumar4

1Department of Research, Saveetha University, Chennai.

2Department of Pharmacology, NRI Medical College, Guntur, AP.

3Department of Research, Saveetha University, Chennai.

4Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Science, Deralakatte, Mangalore.

Corresponding Author E-mail: murtypharma@gmail.com

Abstract: Toevaluate antidiabetic activity of Chloroxylon swietenia in STZ induced diabetes in albino rats  Forty two albino rats were randomly divided into seven groups (n=6). Diabetes was induced by intraperitoneal injection of streptozotocin (60mg/Kg). Distilled water, Tween 80, glibenclamide, Chloroxylon swieteniaaqueous extract(CSAE), ethanolic extracts (CSEE) of 200 and 400mg/kg were given orally for 14 days to the normal control, diabetic control, standard group and test groups respectively. Glucose, TC (total cholesterol), TG (triglyceride), HDL (High density lipoprotein), AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), creatinine, direct bilirubin and indirect bilirubinlevels were estimated. ANOVA followed by Student-Newman-Keuls test was used to analyze the data. CSAE of 200mg/kg showed a significantreduction in glucose, ALT, TB and ALP levels in diabetic rats.CSAE of 400mg/kg showed a significant decrease in glucose, AST, ALT, TB, DB and ALP levels in diabetic rats.CSEE of 200mg/kg showed a significant decrease in glucose, ALT, TB,ALPandcreatininelevels in diabetic rats.CSEE of 400mg/kg showed a significant decrease in glucose, AST, ALT, TB, DB and ALP levels in diabetic rats. Both extracts show antidiabetic activity in STZ induced diabetes.

Keywords: Antidiabetic activity; Chloroxylon swietenia; streptozotocin; AST; ALT; ALP; creatinine and Bilirubin

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