The Study of Growth Factors in Patients with Androgenic Alopecia

A. A. Kubanov^{1, 2}, Yu. A. Gallyamova¹ and O. A. Korableva²

¹Russian Medical Academy of Continuous Professional Education, the Ministry of Healthcare of the Russian Federation, Barrikadnaya St., 2/1, Moscow, 123995, Russia.

²State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation, Korolenko St., 3/1, Moscow, 107076, Russia.

Corresponding Author E-mail: yulya.gallyamova.69@mail.ru

Abstract: Studying the causes of hair loss and improving the methods of alopecia therapy are among the most important trends in dermatology. The interest is determined by the fact that pathogenic mechanisms of hair loss are poorly studied, current methods of therapy are not always effective enough, and the existing theories and assumptions do not reveal fully the mechanisms of hair loss. Undoubtedly, the development of new pharmacological means and methods of alopecia therapy is possible only owing to better understanding of hair loss patterns at the pathophysiological level. The purpose of this study was to investigate the role of the VEGF, KGF, EGF, TGF-β1 growth factors in the development of androgenic alopecia in men and women. This study demonstrates gender differences in the pathogenesis of androgenic alopecia. The obtained data give reason to assume the influence of other factors on the development of androgenic alopecia in men.

Keywords: Androgenic alopecia; hair follicle; hair cycle; hair growth; VEGF; KGF; EGF; TGF-β1

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