Role of IRF6 Gene in Orofacial Clefting: A Systematic Review
Deepak Chandrasekharan1 and Arvind Ramanathan21Department of Orthodontics, Bharath University Chennai, India.
2Sree Balaji Dental College and Hospital Bharath University Chennai, India.
Corresponding Author E-mail: drcdeepak1307@gmail.com
Abstract: The search for the genetic etiology of non syndromic clefting has been pursued for some time now . Amongst the probable genes that could be involved in NSCLP , the IRF6 gene has shown to be linked .With a lot of studies that have implicated the IRF6 gene to NSCLP ,there was a need to have a systematic review of the literature available and to find the association of IRF6 gene to NSCLP . The review was designed to search the common scientific search bases, Pubmeb , Cochrane and Science direct were chosen. Pub med direct displayed 27 , Science direct 50 and Cochrane 0 articles .Further using the specific inclusion criterias comprising a, a direct association of the IRF6 gene mutation to non syndromic orofacial clefting b, human subjects with Non Syndromic Orofacial Clefting , 3 articles were selected . The selected studies found a strong link between the IRF6 gene and Non syndromic Orofacial clefting , reported from different populations around the world.
Keywords: IRF6 gene; Non syndromic clefting; Literature review Back to TOC