Role of MSX1 Gene in Orofacial Clefting : A Systematic ReviewC. Deepak1 and Arvind Ramanathan2
1Department of Orthodonics, Bharath University Chennai, India.
2Sree Balaji Dental College and Hospital Bharath University Chennai, India.
Abstract: MSX1 gene is among the Homeo box genes . The Master genes that control the downstream genes and are involved in the patterning of the face . MSX 1 deficient mice have shown to have cleft palate and missing teeth . Several studies have been done , which have shown a relationship between non syndromic cleft lip and palate and the MSX1 gene . As Human studies on MSX1 and non syndromic clp are rare , this systematic review was done to see if there were sufficient literature to support the same . Three search data bases were taken , , Pubmed , Science direct and Cochrane were searched using the key words . Pub med showed 5 , Science direct 79 and Cochrane 1 articles. Further using the inclusion criteria , 5 articles were selected . Human studies involved populations from across the world .Keywords: MSX1 gene; systematic review; Non Syndromic cleft lip and palate Back to TOC