Plasma CXCL16 Level is Associated With Cardiovascular Disease in Iranian Hemodialysis Patients
Alireza Nazari 1,5, Atlas Mashayekhi Sardoo2, Elnaz Tahmooresi Fard3, Hossein Khorramdelazad4,5, Gholamhossein Hassanshahi5 and Ali Esmaeili Nadimi6,71Department of Urology, Faculty of Medicine, University of Medical Science, Rafsanjan, Iran.
2School of Engineering and Design and Physical Sciences, Brunel University London, London, United Kingdom.
3Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
4Department of Immunology, Faculty of Medicine Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5Molecular Medicine Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran.
6Department of Cardiology, Faculty of Medicine, University of Medical Science, Rafsanjan, Iran.
7Occupational Environmental Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran.
Corresponding Author E-mail: dr_esmaeili_n@yahoo.com
Abstract: Studies have shown that the soluble C-X-C chemokine ligand 16 (CXCL16), a scavenger receptor for oxidized low-density lipoproteins, plays an important role in acute coronary syndrome with atherogenic effects. This study aimed to discover the association between circulating CXCL16 levels in hemodialysis patients (HD patients) with cardiovascular disease (CVD). In this cross-sectional study, we enrolled Two hundred twenty subjects, which included 82 HD patients, 70 HD patients with CVD, and 68 healthy controls, who were referred to the Ali Ebn- Abitaleb Hospital, (Rafsanjan, Iran) from Sep 2014 to Feb 2016. Serum CXCL16 levels were measured by ELISA and other clinical parameters were examined based on standard methods. Our results indicated that serum CXCL16 levels were significantly increased in HD patients with CVD when compared with HD patients without CVD and healthy subjects (p < 0.05). Findings of this study demonstrated that the serum level of CXCL16 can be a potential predictor for the diagnosis of cardiovascular disease in HD patients.
Keywords: Cardiovascular Diseases; CXCL16; chemokine; Hemodialysis Back to TOC