Studying the Correlation Between Serum Level of 25- hydroxyvitamin D and Glucose Metabolism During Pregnancy
Afasaneh Ghasemi1, Roghaye Pourali2*, Jalil Kouhpayeh Zadeh3 and Maryam Akbari2

1Department of Gynecology and Midwifery, Shahid Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran.

2Shahid Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran.

3Department of Social Medicine, Medical School , Iran University of Medical Sciences, Tehran, Iran.

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Abstract: There are conflicting ideas concerning the correlation between serum levels of 25-hydroxivatmin D and side effects of pregnancy. The present research seeks to study the correlation between lack of this vitamin and glucose metabolism in pregnancy. In this Cross-sectional research, as many as 330 women aging 18 to 35 in the 24th to 28th week of their pregnancy and fully aware of the process entered this project after their consent was gained. They underwent public screening for diabetes through 50-gram oral glucose challenge test (GCT). The serum level of HbA1C and 25-hydroxyvitamin D and analysis of urine for glucose were measured at the same time when the level of blood sugar was assessed. As for those people whose blood sugar 1 hour after receiving 50 g oral glucose was equal to or more than 140 mg/dl, the two-hour OGTT diagnosis test was carried out with 75 grams of glucose. The average levels of Vitamin D and HbA1C were compared with one another among the participants. Variables such as mother’s age, parity, family history of diabetes, and BMI of mother were recorded in the checklists. Data was analyzed by SPSS20 software using T-test, Correlation, and K2 statistical methods. The average age of the mothers participating in this research and their average level of parity were 26.78 ± 4.5 and 1.89 ± 0.92 respectively. There were 48 cases (14.5%) with pregnancy diabetes, while 282 cases (85.5%) had no sign of diabetes. The serum level of vitamin D was above 30 ng/dl in 9 subjects (2.7%), while this level was below 20 ng/dl in 321 people (93.7%). A reverse significant correlation was observed between the serum level of vitamin D and average levels of HbA1C (p=0.006 and r=0.15). a significant difference was observed in Glucosuria between the diabetic and non-diabetic people (p=0.001) but it had no significant correlation between the level of vitamin D. Prevalence of vitamin D deficiency in this research is really high. The routine assessment of this vitamin before pregnancy and the necessity of correcting its deficiency and prescription of vitamin d supplements and its effect on OGTT results,needs more researches more researches.

Keywords: 25-hydroxivitamin D; gestational diabetes; Glucose Metabolism

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