Upregulation of Rarb, Rarg, and Rorc Genes in Clear Cell Renal Cell CarcinomaAnna Viktorovna Kudryavtseva1,2,*, Kirill Mikhailovich Nyushko2, Andrew Rostislavovich Zaretsky3,4, Dmitriy Alekseevich Shagin3, Andrey Dmitrievitch Kaprin2, Boris Yakovlevich Alekseev2 and Anastasiya Vladimirovna Snezhkina1
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
2National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
3Pirogov Russian National Research Medical University, Moscow, Russia.
4Evrogen Lab LLC, Moscow, Russia.
Abstract: Clear cell renal cell carcinoma (ccRCC) is one of the most frequent urological malignancies with a high mortality rate. The search for genes that could be potential targets for therapy as well as diagnostic and prognostic markers is an important task. In this work the expression of nine genes, encoding nuclear retinoid receptors, in ccRCC was analyzed by bioinformatics and quantitative PCR methods. We have identified the upregulation of RARB, RARG, and RORC genes that encode RAR-beta, RAR-gamma, and ROR-gamma nuclear retinoid receptors, correspondingly. As is well known, all of them can bind trans-retinoic acid. It allows assuming that the nuclear retinoid receptors may play significant role in the alterations of retinoic acid metabolism in ccRCC and contribute to the diseases progressionKeywords: clear cell renal cell carcinoma; nuclear retinoid receptors; gene expression; quantitative PCR Back to TOC